New CITP preprint! Lifespan and health effects of 17α-estradiol, acarbose, green tea extract, nordihydroguaiaretic acid, and rapamycin across a Caenorhabditis genetic diversity panel
The Caenorhabditis Intervention Testing Program (CITP) is an NIH-funded research consortium that includes the Phillips lab at the University of Oregon, the Driscoll lab at Rutgers University, and the Lithgow lab at the Buck Institute. The founding principle of the CITP is that compounds effective across a genetically diverse panel of Caenorhabditis species and strains are likely engaging conserved biochemical pathways to exert their effects. In this manuscript (bioRxiv) the CITP describes their characterization of the longevity and health effects of five compounds previously described as having potential anti-aging effects (17α-estradiol, acarbose, green tea extract, nordihydroguaiaretic acid, and rapamycin) across a Caenorhabditis genetic diversity panel.
