New publication in Aging!

The next Caenorhabditis Intervention Testing Program [CITP] publication is now available [link]. In this manuscript we characterized the relationship between lifespan and health, and the influence of genetic background on that relationship, in a panel of Caenorhabditis nematodes. We combined multiple measures of health (survival under thermal and oxidative stress and swimming performance) to evaluate health effects for three compounds – NP1, propyl gallate, and resveratrol. We show that oxidative stress resistance and thermotolerance vary with compound intervention, genetic background, and age. The effects of tested compounds on swimming locomotion, in contrast, are largely species-specific. Additionally, thermotolerance, but not oxidative stress or swimming ability, correlates with lifespan. Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible aging interventions.