New publication in Geroscience!

The next Caenorhabditis Intervention Testing Program (CITP) has now been published [link]. The CITP looks for intervention candidates that have positive effects across a genetically diverse panel of Caenorhabditis species. In this paper we present a streamlined evaluation pipeline and data from studies of five compounds previously shown to extend C. elegans lifespan or thought to promote mammalian health Those compounds were 17α-estradiol, acarbose, green tea extract, nordihydroguaiaretic acid, and rapamycin. Overall, our analysis supports the position that genetic background and assay type influence lifespan and health effects of compounds, and that lifespan and health can be uncoupled by chemical interventions.